教育
- B.S., Pharmacy, School of Pharmacy, Shanghai Medical University
- M.S., Chemistry, College of Arts and Sciences, University at Albany
- Ph.D., Pharmaceutical Science, School of Pharmacy, University of Connecticut
acphs所教授的课程
- 制药学我 & II
- 制药和分析技术
- 药学研究经历
- 植物药物
- 药物作用的分子基础
- 高级药剂学I & II
- 给药原则
- 管理科学
- 药品稳定性
- 药剂学专题
- 论文研究
- 高级药学实践经验(APPE)
研究兴趣
复杂药物产品(CDP)具有复杂的物质, 配方, 和/或机制, 很难用化学方法来描述, 制定身体, 评估生物, 并进行临床评估. 我们的研究是为行业提供见解, 监管机构, 和临床医生提高质量, 安全, 功效, 认可, 以及患者对CDP的负担能力. Zheng’s group integrated an array of interdisciplinary approaches including structural-based drug 设计, 计算机建模, 配方设计, 分子鉴定, and bioanalytical testing to close the gaps between product quality and clinical effects of:
- 生物制剂, 生物仿制药, 多肽:研究, 设计, 制定, 开发, 并评估质量, 治疗性蛋白和多肽的有效性和安全性.
- Botanical Drug Products (BDP) are made from natural complex substances. 我们运用分析技术, 转化策略, and cutting-edge tools to demystify medicinal plants that can be 开发ed into pharmaceutical or wellness products.
- Endocannabinoid System (ECS) 研究: Cannabis is one of the most used and studied botanicals. The discovery of cannabinoids and then endocannabinoids revealed more fascinating molecular mechanisms between cannabinoids and the ECS. Dr Zheng has been focused on investigating the mechanisms of ECS and the “endocannabinoidome”, especially the ECS across the blood brain barrier (BBB) between the central nervous system and peripheral circulations. These studies are promising to unlock ECS’ therapeutic potentials for stroke, 受伤, 疼痛, 退化性疾病, 和物质使用障碍(SUD).
These research projects help to empower patient-centered product 设计, 加强药物开发, 支持监管决策, 降低风险, 包括滥用药物.
投稿书籍(精选)
- 马丁的物理药学和药物科学, 第七版, 帕特里克·辛科编辑, Lippincott威廉姆斯 & 威尔金斯,2017.
- Shargel and Yu’s Applied Biopharmaceutics and Pharmacokinetics, 第八套广播体操, Murray P . Ducharme和Leon Shargel编辑, 麦格劳-希尔, 2021
出版物(选择)
科菲·哈根, Panayiotis万利拉, 海安郑*, Endocannabinoid System of the Blood-Brain Barrier -- Current Understandings and Therapeutic Potentials, 大麻和大麻素研究, 2022, 10月,7 (5):561 - 568
斯凯勒Pruyn, 贾斯汀弗雷, 迈克尔Brodeur, 本杰明•贝克, 希瑟长, 卡拉Graichen, 海安郑*, 迈克尔Dailey *, Quality Assessment of Expired Naloxone Products from First-Responders’ Supplies, 院前急诊医学杂志, 2018年12月30:1-7
nas Z. 珍妮·阿尔沙里夫. Dennis Williams，郑海安，David N. Ombengi, Adnan Dakkuri, 莎拉Al-Dahir, 托Tofade达乌度, 苏珊娜Gim, 玛丽·贝思·奥康奈尔, Global/International Advanced 药房实践 Experiences (part 1): Host Country, 场地及院校考虑, (AACP Special Article on Global Pharmacy Education) American Journal of Pharmacy Education, 25;80(3):38. 2016
郑海安，James Truong, Fred Carroll, Manjunath P. 拜, Do Formulation Differences between Reference Listed Drug and Generic Products of Piperacillin-Tazobactam Impact Reconstitution? Antimicrobial Agents and Chemotherapy, 59 (3) 1767-1769, 2015.
Dominique Pepe, Melissa McCall，郑海安，她曾B. 洛佩斯, Protein Transduction Domain-containing Microemulsions as Cutaneous Delivery Systems for an Anticancer Agent, 药学杂志, 102(5): 1476-87, 2013
她米. 霍斯默，申秀，Adwoa Nornoo，郑海安. 她曾B. 洛佩斯, Influence of Internal Structure and Composition of Liquid Crystalline Phases on Topical Delivery of Paclitaxel, 药学杂志, 100(4):1444-1455, 2011
她曾B. 洛佩斯，希拉里·范德沃尔，辛辛·T. Li, Vijay Venugopal, Hsin K. Li, Stan Naydin, Jaclyn Hosmer, Mark Levendusky, 海安郑, M. 维多利亚L.B. 本特利，罗伯特·莱文，玛莎·A. 哈斯, Topical Delivery of Lycopene Using Microemulsions: Enhanced Skin Penetration and Tissue Antioxidant Activity, 药学杂志, 99: 1346-1357, 2010
Adwoa Nornoo, 海安郑, 她曾洛佩斯, 鲍里斯Johnson-Restropo, Kurunthachalam Kannan, 雷切尔里德, Oral Microemulsions of Paclitaxel: in-situ and pharmacokinetic studies. European Journal of Pharmaceutics and Biopharmaceutics, 71(2), 310-317, February 2009
海安郑, 桔多琪赵, WanYun盛, Xiang-Qun谢, A Transmembrane Helix-bundle from G-protein Coupled Receptor CB2: Biosynthesis, 净化, 核磁共振表征, 生物聚合物83 (1):46 - 61, 2006
海安郑, 桔多琪赵, 蜀王, CM林, 托马斯•陈, 大卫。琼斯, 斯坦利Opella, Xiang-Qun谢, Biosynthesis and 净化 of a Hydrophobic Peptide from Transmembrane Domains of G Protein Coupled CB2 Receptor, 肽研究杂志, 65(4):450-8, 2005
Xiang-Qun谢, 桔多琪赵, 海安郑, 表达式, 净化, GPCR蛋白片段的同位素标记, CB2(180-233), 蛋白表达与纯化, 38(1):61-8, 2004
会议及演讲(精选)
伊米莉亚Johnson-Viola, Dua阿訇, 尼古拉•林, 科菲·哈根, 杰弗里·沃伊特, 马塞尔Musteata, 海安郑, The Potential Effect of Cannabinoids on Drug Permeability across the Blood Brain Barrier (BBB), 第24届AAPS-NERDG年会, 哈特福德, CT, 4月22日, 2022
科菲·哈根, 安德鲁·瑟斯顿, 马塞尔Musteata, 杰弗里·沃伊特, 亚历杭德罗亚当, 哈亚, Alexandros马克里扬尼斯, 海安郑, Endocannabinoids may modify and regulate the Blood Brain Barrier (BBB) permeability, 快速火力演示, 第23届AAPS-NERDG年会, 虚拟, 4月16日, 2021
安德鲁·瑟斯顿, 斯凯勒Pruyn, 杰弗里·沃伊特, 马塞尔Musteata, 哈亚, Alexandros马克里扬尼斯, 海安郑, Endogenous Cannabinoid System at the Blood Brain Barrier: Distributions and Functions of Endocannabinoids, 第四届药物滥用化学与药理学, 波士顿, 硕士八月一日, 2019
斯凯勒Pruyn, 安德鲁·瑟斯顿, 海安郑, Biodistribution and Functions of Endocannabinoids Across the Blood Brain Barrier under Normal and Ischemic Conditions, 29th Annual International Cannabinoid 研究 Society Symposium, 贝塞斯达, MD, 6月2日, 2019
Frey J, Pruyn S, Brodeur M, Baker B, Graichen C, Dailey M, Zheng H. Quality Assessment of Expired Naloxone Products from First Responders’ Supplies. AACP年会，马萨诸塞州波士顿，2018年7月22日.
Thurston AB, Zheng HA. Cannabinoid Receptor 表达式 on Human Embryotic Kidney Cells (HEK-293) and the Factors that Influence them. Chemistry and Pharmacology of Drug Abuse, 波士顿 MA, August 2, 2018
海安郑, 珍妮林, 朱迪腾, Re设计 Regulatory Science Course for both PharmD and 研究生, AACP年会, 纳什维尔, 田纳西州. 2017年7月15日至19日
内森Spaziani, Ayush深, 安德鲁·瑟斯顿, 海安郑, System Pharmacognosy Mapping of Phyto-cannabinoids for CB1/ CB2 Activity and Specificity, The 27th Annual International Cannabinoid 研究 Society Symposium, 蒙特利尔, 魁北克, 6月22 - 27日, 2017
凯蒂·E. Cardone, 海安郑, 尼古拉斯犹豫, 凯文Rivenburg, 罗伯特•汉密尔顿, Promoting Pharmacy through Recruitment for Two 校园es in Two States, AACP年会, 阿纳海姆, CA, 7月23日, 2016
Nouf Alanzi, 圣扎迦利Novakovic, 帕特里夏·格拉索, 海安郑, Structures and Interactions between Leptin Receptor and Leptin-Based Peptides, 美国儿科学会年会, 圣地亚哥, CA, 11月2 - 6, 2014
安娜Stonemen, 援助yanne托雷斯, 海安郑, 迈克尔Brodeur, Stability of Epinephrine in Expired EpiPen Products from EMS Ambulances, 美国儿科学会年会, 圣地亚哥, CA, 11月2 - 6, 2014
海安郑, 雷切尔苏斯曼, 雷切尔史密斯, Francelyse Leveille, 瑞恩•沃森, 盖尔Goodman-Snitkoff, PharmaDA$HTM: An Interactive Game of Drug Development and Approval Process for IPS Workshop, AACP年会, 基, FL, 7月14 - 18, 2012
马修·雅各布, Yennhi阮, Francelyse Leveille, 阿米特拜, 海安郑, Pharmacokinetics and Nephro-toxicity Monitoring of Gentamicin, 美国儿科学会年会, 华盛顿特区, 10月27日, 2011
Roshan Tasgaonkar, Nikolaos G. 田建辉，田建辉，李建辉，李建辉. 加西亚, 海安郑, In Silico Formulation: Insulin Stability and Molecular Dynamics by Computer Simulation, FIP制药科学2010年世界大会 & 美国儿科学会年会和博览会，新奥尔良，洛杉矶. 2010年11月14日至18日
海安郑, 灵阮, 荀龚, 她曾洛佩斯, 朱迪腾, Pharmaceutics in Motion: Embracing Computer Modeling and Multimedia Presentation in Pharmacy Education. AACP年会 and Seminars, Seattle, WA July 10-14, 2010
帕特尔的故事, 海安郑, 凯蒂Cardone, Stability Study of Extemporaneously Prepared Sodium Thiosulfate Injections, AAPS东北地区年会, 洛矶山, 4月23日, 2010
新T. 李，卢西安娜·洛佩斯，郑海安，玛莎·A. 理查德·E·哈斯. 杰弗里·M·迪尔伯恩. 沃伊特, 研究-based Instructional Laboratory for a Pharmaceutical Analytical Techniques Course, AACP年会, 波士顿, 7月18日至22日, 2009
宝拉黄, 克里斯Policastro, 利昂娜Bluestein, 海安郑, Pharmaceutics Online-首页work: Calculation Practice and Evaluation in Large-Class, AACP年会, 芝加哥, IL, 2008年7月
Adowa Nornoo和郑海安, Pharmacokinetics 核磁共振表征 of Paclitaxel Microemulsion, 美国儿科学会年会, 圣地亚哥, 2007年11月